First Author: M.Iqbal PAKISTAN
Co Author(s): A. Aftab
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We compared the beneficial effects of intravitreal bevacizumab (IVB) versus PRP in regression of new vessels in treatment naïve eyes with PDR.
Khyber Teaching Hospital, Peshawar, Pakistan
This randomized control trial pilot study was conducted to evaluate the feasibility of the multicentre trial. Patients with treatment naïve PDR were recruited. Randomization was carried out using a custom made software. Pre-treatment examination was carried out including fluorescein angiography and optical coherence tomography. Area of leakage on FFA was measured in mm2 using the custom made software. In IVB group 4 weekly injections were administered for 3 months. In PRP group, PASCAL laser was used to carry out macular grid and PRP in two sessions at least 4 weeks apart. After 3 months of treatment repeat FFA and OCT ware performed
Eyes included in this trial were 9 eyes from 5 patients. 5 patients were randomized into IVB group while 4 patients were in PRP group. IVB group had complete regression of leakage (92.42 ± 159.48 mm2 vs zero mm2), while PRP group demonstrated partial regression (499.22 ± 465.19 mm2 vs 74.00 ± 86.31 mm2) at 12 weeks.
IVB seems superior to PRP in regression of new vessels in treatment naïve eyes with PDR at least in the short term