First Author: S.Gedik TURKEY
Co Author(s): A. Bozkurt Oflaz B. Turgut Ozturk B. Bakbak S. Gonul S. Okudan
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To measure the effect of intravitreal dexamethasone implant (Ozurdex®, 0.7mg) on aqueous flare in patients with unilateral central retinal vein occlusion on the effected and the healthy eye.
Thirty patients with unilateral central retinal vein occlusion complicated with macular edema have been enrolled into the study. Aqueous flaer measuremments of healthy and affected eyes were measured for each patient before the injection and at the first day and first month after injection with FM-700 Laser Flare Meter (Kowa Company, Japan). The significance of the differences of aqueous flare measurements before and after the injection of dexamethasone implant in healthy and affected eyes were assessed with Mann-Whitney U test. Similarly the significance of differences of aqueous flare measurements between healthy and affected ayes before and after the injection of dexamethasone implant were evaluated by Mann-Whitney U test (SPSS 15.0). P values <0.05 were taken as statistically significant.
The difference of aqueous flare measurements before intravitreal dexamethasone implant injection and after the injection between affected and health eyes, was statistically significant (p>0.05). In the affected eyes, the differences of the results of aqueous flare measurementsbefore and after the injection at first day and first month were statistically significant (p=0.023 and p=0.001, respectively). Additionally the difference in aqueous flare measurements between the first day and first month was also statistically significant (p=0.018). In the healthy eyes the difference of aqueous flare measurements before injection and at the first day was not statistically significant (p=0.093); interestingly the difference at the first month was statistically significant (p=0.001).
Intravitreal dexamethasone implant decreases aqueous flare at the first day and at the first month progressively in eyes with central retinal vein occlusion induced macular edema. The decreasement in aqueous flare at the first month in the healthy eyes may be secondary to systemic effect of intravitreal dexamethasone implant.