Bilateral simultaneous central retinal vein occlusion in hyperviscosity retinopathy with good response to immunosuppressive therapy

Poster Details

First Author: M.Blau Most ISRAEL

Co Author(s):    A. Ohayon   A. Rubowitz                          

Abstract Details


To describe the clinical presentation and imaging features of a patient who presented with bilateral central retinal vein occlusion (CRVO), was diagnosed with hyperviscosity retinopathy due to B cell lymphoproliferative disease (most probably Waldenstrom's macroglobulinemia), and had good response to systemic immunosuppressive therapy.


Meir Medical centre, Kfar-Sava, Israel.


A clinical case report of an 87-year-old woman who presented with bilateral CRVO. Visual acuity, clinical examination, spectral domain optical coherence tomography (SD-OCT), colour fundus photography and systemic evaluation were obtained.


Ocular examination at presentation revealed bilateral CRVO, with bilateral diffuse dilated and tortuous retinal veins, intraretinal deep blot haemorrhages in all four quadrants of both eyes. OCT examination revealed significant central macular edema bilaterally. Six months after the diagnosis of hyperviscosity retinopathy and administration of systemic cyclophosphamide immunosuppressive therapy for the B cell lymphoproliferative disease, almost all of the retinal haemorrhages resolved and there was partial resolution of the macular edema.


This case describes the association between bilateral simultaneous CRVO and hyperviscosity retinopathy diseases such as Waldenstrom's macroglobulinemia. Administration of systemic immunosuppressive therapy was found to be beneficial for this patient.

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