First Author: Y.Sim SOUTH KOREA
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The aim of the study was to investigate the characteristics of ocular toxocariasis (OT) presenting with intermediate uveitis in the Korean population.
The medical records of all patients diagnosed with intermediate uveitis at St. Vincent’s Hospital, Suwon, Republic of Korea, between 2014 and 2016 were retrospectively reviewed.
Inclusion criteria included patients diagnosed with naive intermediate uveitis without retinal lesion and no known related disease until the first visit, with a follow-up of at least 6 months after the first diagnosis and treatment. All patients diagnosed with OT were treated with oral steroids with tapering in 2 months, and with 400mg albendazole twice per day for 2 weeks to minimize recurrence. We classified all intermediate uveitis patients who were seropositive for Toxocara IgG into the OT group, and those who were eronegative into the non-OT group. Sex distribution, age, bilaterality, IgE levels, eosinophil counts, and complications were compared between the 2 groups. We analyzed the baseline clinical characteristics, IgE levels, eosinophil counts, suspected infection routes, optical coherence tomography (OCT) (Cirrus High Definition-OCT; Carl Zeiss Meditec, Dublin, CA) to check complications, changes in IOP and BCVA after treatment, and recurrence rates and complications like cystoid macular edema (CME) or epiretinal membrane (ERM) until 6 months in OT patients.
We studied intermediate uveitis patients using ocular and systemic evaluations and a Toxocara IgG serology test. Of 50 intermediate uveitis patients, 19 were seropositive for Toxocara IgG. Of the 19 OT patients, 4 presented with recurrence within 6 months and were significantly younger than nonrecurrence patients (P=0.009). Thirteen patients had a history of eating raw cow liver. There were 14 males and 5 females in the OT group, and 11 males and 20 females in the non-OT group (P=0.009). There was bilateral involvement in 7 out of 19 patients in the OT group, and 20 out of 31 patients in non-OT group (P=0.033). Intermediate uveitis patients in OT were predominately male and had more unilateral presentation than non-OT patients.
The prevalence of OT was 38.00%in intermediate uveitis patients in the Korean population. In cases of intermediate uveitis, the possibility of OT should be considered, and knowledge of eating history and toxocariasis serological tests should be performed. Young patients have a higher recurrence