Managing cluster endophthalmitis cases after intravitreal bevacizumab (Avastin®) injection.

Poster Details

First Author: S.Parikh INDIA

Co Author(s):                                 

Abstract Details


To describe clinical presentation and management of cluster endophthalmitis after intravitreal Avastin® injection.


The study was carried out at Nagri Eye Research Foundation, Ahmedabad.


The study shows retrospective analysis of 16 patients who underwent intravitreal Avastin® injection from the single vial on the same day. All the patients developed intraocular inflammation on the next day of the injection. All the patients underwent anterior chamber and vitreous tap followed by intravitreal antibiotic and steroid. All the patients underwent surgery (vitrectomy) along with intravitreal antibiotic and steroid. All the patients were followed up for 6 month after the surgery


Culture report for aqueous and vitreous tap was negative in all the eyes. All the patients were recovered from intraocular inflammation after the surgery. None of the patients developed severe complications due to endophthalmitis. 3 eyes developed cataract after surgery. 13 eyes from 16 had recovered pre-Avastin® vision within 1 month of the surgery. 8 eyes out of 13 improved vision within 3 months of surgery.


Off label use of intravitreal Avastin® can give rise to cluster endophthalmitis. Early intervention and surgery is the key factor for successful visual outcome.

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