First Author: K.Nakai JAPAN
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To characterize patients with Vogt-Koyanagi-Harada (VKH) disease with choroidal folds (CFs) and determine how the foveal choroidal thickness changes after initial treatment using high-penetration optical coherence tomography (HP-OCT).
Retrospective case series / Osaka University Hospital
In this retrospective observational study, we analyzed 42 eyes of 21 patients with new-onset VKH disease to determine the demographic and clinical differences between patients with and without CFs.
Twenty-four (57.1%) eyes of 13 patients with VKH disease had CFs. The mean age of patients with CFs was significantly (p=0.0009) higher than that of those without CFs (49.1 vs. 39.4 years, respectively). The frequency of disc swelling was significantly (p=0.0001) higher in eyes with CFs than in those without CFs (95.8% vs. 38.9%). The choroidal thickness at the first visit was significantly (p=0.0011) greater in eyes with CFs than in those without CFs (794 ± 144 μm vs. 649 ± 113 μm). The choroid 6 months after the initial treatment was significantly (p=0.0118) thinner in eyes with CFs than in those without CFs (270 ± 92 μm vs. 340 ± 80 μm). The frequency of sunset glow fundus at 6 months in eyes with CFs was significantly (p=0.0334) higher than in those without CFs (62.5% vs. 27.8%).
The development of CFs in patients with VKH disease was significantly correlated with age, disc swelling, and choroidal thickness. The eyes with CFs frequently developed a sunset glow fundus. The findings suggested that patients with CFs might have severe and longstanding inflammation of choroidal tissues.