Posters

Ocular sarcoidosis: Report of two cases

Poster Details

First Author: K.Montes-Leon COLOMBIA

Co Author(s):    F. Rodriguez Alvira   R. Infante De German R                          

Abstract Details



Purpose:

To describe the posterior segment findings of two patients with multiple organ involvement due to systemic sarcoidosis biopsy-proven.

Setting:

To describe the posterior segment findings of two patients with multiple organ involvement due to systemic sarcoidosis biopsy-proven.

Methods:

Report of two cases. Clinical examination, fundus imaging, fluorescein angiography and macular spectral domain optical coherence tomography were performed, as well as chest x-ray, chest computed tomography (CT), and skin and lung biopsy-proven.

Results:

Two female patients, 55 and 69 years-old, reported bilateral decreased vision, floaters and flashes. First patient begins symptoms two weeks ago, with better corrected vision in right eye (OR) 20/20 and left eye (OS) 20/25, anterior segment unchanged, normal pressure, little vitreous cellularity with inflammatory deposits on the retina, and peripheral evanescent white spots (more in right eye). Fluorescein angiography showed peripheral vascular sheathing in late phases. Second patient reported symptoms three years ago with increased floaters and flashes two days before, better corrected visual acuity OR 20/80 and OS 20/50, tyndall (greater OS), fine keratic precipitates, vitreous cellularity, and cystoid macular edema. Macular SD–OCT OR conforms diffuse edema, microcysts, macrocysts and increased central foveal thickness (386 um). Chest CT revealed parahilar and mediastinal lymphadenopathy in both patients. Skin biopsy (first patient) and lung biopsy (second patient) showed granulomatous inflammation with epithelioid cells and lymphohistiocytic infiltrate; histological findings suggested sarcoidosis. Systemic, topical and intravitreal corticoid treatment was dispensed including intravitreal dexamethasone implant 700ug, with bilateral visual stability.

Conclusions:

The manifestations of sarcoidosis in the posterior segment, although infrequent, present as non-infectious uveitis with cystoid macular edema and/or peripheral vasculitis, bilateral visual involvement, and variable response to corticoid treatment.

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