First Author: E.Cetin TURKEY
Co Author(s): K. Bozkurt S. Akbulut G. Pekel
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To assess the change in peripapillary retinal nerve fibre layer (RNFL) thickness and macular segmentation in patients with anterior uveitis.
Tertiary referral hospital
The study included analysis of 33 eyes of 24 patients with anterior uveitis and 48 eyes of 48 age and gender matched healthy subjects. Patients with posterior uveitis findings were excluded. Peripapillary RNFL thickness measurement and macular segmentation analysis were performed by spectral-OCT. The thicknesses of RNFL, ganglion cells, inner plexiform, inner nuclear, outer plexiform, outer nuclear and photoreceptor layers and retinal pigment epithelium (RPE) in central, superior, nasal, inferior and temporal sectors were documented in the study and the control groups.
The thicknesses of superotemporal peripapillary RNFL and all sectors in RPE and photoreceptor layers were significantly thinner in the study group than that in the control group (p<0,05). On the contrary, the thicknesses of nasal and central inner nuclear and central outer plexiform layers were significantly thicker in the study group than that in the control group (p=0,007, p=0,010 and p=0,005 respectively). When eyes with active uveitis (21 eyes) were compared with eyes with inactive uveitis (12 eyes), macular layers were not significantly different but central and nasal peripapillary RNFL were significantly thinner in the inactive uveitis group (p=0,006 and p=0,049 respectively).
There were significant alterations in peripapillary RNFL and inner and outer macular layers in patients with anterior uveitis. More data are needed to document the quantitative retinal changes in this group of patients in long term.