Posters

Experience with anti-VEGF therapy of idiopathic neovascular membranes in children and teenagers – Case reports

Poster Details

First Author: B.Babkova CZECH REPUBLIC

Co Author(s):    Z. Pracharova   J. Simicak   O. Vlacil   M. Rybarikova                    

Abstract Details



Purpose:

We monitored the effects of anti-VEGF therapy in form of intravitreal injections of ranibizumab on the achieved functional and anatomical result, with young patients with idiopathic or myopic NV membrane

Setting:

We monitored three children patients with diagnosis of idiopathic neovascular membrane. In the case reports, we monitored improvement of functional results on ETDRS optotypes and anatomic improvement on OCT. We evaluated the number of intravitreal injections dosed in analgosedation/general anaesthesia, required to stabilize the finding.

Methods:

The children were examined by BCVA, biomicroscopy of anterior and posterior eye segment, angiography, OCT, photodocumentation along with a general rheumatology and uveology screening upon entrance. With this set of methods, we monitored the patients on the day of application, one day after application, one week after application and then on monthly basis.

Results:

In the first patient (girl aged 10 years) the application of two injections resulted in stabilized finding, improvement of visual acuity of 23 letters on ETDRS optotypes and reduction of macular thickness of 135 microns. In the second patient (boy, 10 years) the application of three injections resulted in stabilized finding, improvement of visual acuity of 21 letters on ETDRS optotypes and reduction of macular thickness of 131 microns. In the third patient with myopic membrane (boy, 16 years) the application of three injections also resulted in stabilized finding, improvement of visual acuity of 3 letters on ETDRS optotypes and reduction of macular thickness of ~230 microns.

Conclusions:

In all three monitored children patients, we have found improvement of central visual acuity on ETDRS optotypes, reduction of central macular thickness and regress of edema on OCT. Two or three intravitreal anti-VEGF (ranibizumab) injections were sufficient to stabilize the finding. This therapy is an effective and safe method in children patients with diagnosed myopic and idiopathic CNV.

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