Intrinsically photosensitive retinal ganglion cell and pupil reaction for blue light after cataract surgery

Poster Details

First Author: M.Kuze JAPAN

Co Author(s):    T. Koyasu   K. Tsubota   M. Ayaki                       

Abstract Details


Cataract decreases the transmission of wide-width wavelength light into the eye, and thus, may interfere not only with vision but also circadian rhythm and quality of life. The intrinsically photosensitive retinal ganglion cell (ipRGC), which has a peak sensitivity to blue light (470 nm), plays an important role in circadian rhythm. The increased transmission of different coloured stimuli that occurs after cataract surgery has not been fully evaluated. Therefore, using pupil reaction as a sensitive parameter to assess light transmission, we evaluated the change in pupil reaction to white and blue light stimulation after cataract surgery.


This study was conducted at ophthalmology clinic of Mastusaka Central General Hospital and Nabari Municipal Hospital, which specialized in ophthalmic surgeries.


The study was conducted on 26 eyes with cataract (grade 2.1±3.4) from thirteen patients (average age, 76.2 years) undergoing cataract surgery with implanted intraocular lenses (OptiBlue®, Abbott Medical Optics Inc. Santa Ana, USA). We used two coloured light-emitting diode stimuli of white (463, 563 nm) and blue (470 nm), with a stimulus duration of 1 second. The diameter of the pupil before stimulation was set as baseline and the post-illumination pupillary response (PIPR) was measured using the pupillometer (FP-10000 II; TMI Inc, Japan) and image analyzing software (View Shot; TMI Inc).


The mean diameter of the pupil (mm) was 3.26±0.79 before surgery and 3.26±0.76 after surgery. The PIPR was significantly different between white light (3.25% ± 2.22%) and blue light (4.08% ± 2.29%) before surgery (P < 0.001, t test), as well as after surgery (white, 4.01% ± 1.79%; blue, 6.95% ± 3.71%; P < 0.001, t test). After surgery, the increase in PIPR was significantly greater for blue light (2.83% ± 2.11%) than for white light (0.89% ± 1.14%; P < 0.001, t test).


The pupillary light reaction to both white and blue light increased, with the response greater for blue light which is driven by ipRGC after cataract surgery.

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