Factors associated with elevated pain after anti-VEGF intravitreal injection (IVI)

Poster Details

First Author: F.Filippo SWITZERLAND

Co Author(s):    N. Isabelle   B. Ciara   A. Aude   M. Irmela                    

Abstract Details


This study aimed to assess the pain experienced 1 minute and 3 days after IVI and to identify possible risk factors for elevated pain.


Jules Gonin Eye Hospital


This was a prospective study on the pain experienced by patients with IVI of anti-VEGF treatments. Consenting patients completed a questionnaire of their physical and mental health and degree of pain experienced 1 minute and 3 days after the intravitreal injection.


228 patients participated to the study; 1 minute afetr the intravitreal injection 69 patients (30.3%) reported pain and 3 days after IVI 46 (20.2%) reported pain. Using multivariate analysis for elevated pain, the risk factors identified at 1 minute were, female gender (p=0.03), high preoperative anxiety (p<0.00), low level of well-being (p=0.01) and short anaesthesia time (p=0.05). At 3 days after the injection, identified risk factors were regular use of ocular drops (p=0.03) and high preoperative anxiety (p<0.00).


1 minute after IVI, woman in poor health with elevated anxiety and allowed a short anaesthesia time, have the highest risk of experiencing pain. Whereas, those anxious prone patients whom regularly use ocular drops are at increased risk of experiencing prolonged pain.

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