First Author: T.Torrent Solans SPAIN
Co Author(s): M. Bozal de Febrer F. March de Ribot M. Zapata Victori
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It is being more commonly accepted that Diabetic Macular Edema (DME) is a result of an injury in vasculature, neural cells and inflammation of the retina. We aim to detect differences in the vascular and neural layer in patients with DME. The purpose is to compare Subfoveal Choroidal Thickness (SCT) and Ganglion Cells Layer Thickness (GCLT) of diabetic eyes with and without Diabetic Macular Edema (DME) using Spectral Domain optical coherence tomography (SD-OCT)
Hospital Universitari de Girona Dr. Josep Trueta, Girona, Spain Hospital Universitari de la Vall d'Hebrón, Barcelona, Spain
Two homogenous groups of type 2 diabetic patients with and without Macular Edema (ME) were followed during 2 years. Control Group was made of 40 patients with a mean age of 63 (65% men- 35% women). They had no DME and a maximum of level 35 of the ETDRS scale. This group was only observed during 2 years. Study Group was made of 50 patients with DME, with a mean age of 65 (56% men-44% women). These patients were treated with anti-Vascular Endothelial Growth Factor (anti-VEGF) and/or Laser treatment according the guidelines of Clinical Practice. All patients were submitted to a Macular SD-OCT Zeiss Cirrus Model using the EDI option and 2 observers manually measured SCT. The device automatically measured GCLT.
SCT was measured in 37 Control patients and 34 Study patients and no statistical differences were found (t=-0,288, p=0,724). A total of 292 measurements of SCT were performed during the 2-year period of the Study and the General Additive Method (GAM) could not find any difference between both groups. GCLT was measured in 39 Control patients and 41 Study patients and thinner GCL was detected in the later group with a statistical significance (t=3,16; p= 0,00263). A total of 446 measurements of GCL Thickness were performed during the 2-year period and the GAM showed a clear thinning of GCL in Study patients even though they were being treated with anti-VEGF and laser.
No difference was found in SCT between both groups, even after the two-year period. Clear difference was found in GCLT in the Study Group even with treatment.