Differences in abnormal areas between infrared autofluorescence images and late-stage indocyanine green angiography images in eyes with central serous chorioretinopathy

Poster Details

First Author: A.Shinojima JAPAN

Co Author(s):    K. Tanaka   H. Onoe   H. Shimada                       

Abstract Details


To clarify the differences in abnormal areas between infrared autofluorescence (IR-AF) images and late-stage indocyanine green angiography (ICGA) images after 30 minutes in patients with chronic central serous chorioretinopathy (CSC).


Retrospective case series


We retrospectively studied 22 consecutive untreated CSC patients using IR-AF and ICGA at Nihon University Hospital, Tokyo, Japan. IR-AF images were obtained before performing ICGA using the Spectralis HRA + OCT, which has the advantages of confocal scanning laser ophthalmoscopy (Heidelberg Retina Angiograph + OCT, Heidelberg Engineering, Germany). These images were taken on the same day. We compared the sizes of abnormal areas in the 23 CSC eyes (including one case with bilateral CSC) and 21 without serous retinal detachment (SRD) in contralateral eyes on IR-AF images versus ICGA images after 30 min. The results were analyzed using the unpaired t-test. We used prototype software in the machine to measure the abnormal area within an 8.9 × 8.9 mm area.


Twenty-two consecutive untreated CSC patients (18 men; 19 CSC eyes and 17 contralateral eyes without SRD, 4 women; 4 CSC eyes and 4 contralateral eyes without SRD) were enrolled. The mean patient age was 51.7 ± 13.5 years (range, 31–77 years). Steroid users were excluded from this study. Thirteen Smokers were included in the study (59%). The mean disease duration was 15.5 ± 19.9 months (range, 0.25–72 months). All 23 CSC eyes and 15 contralateral eyes without SRD showed abnormal areas on both IR-AF images and late-phase ICGA. The abnormal area was 9.8±10.8 mm2 in the IR-AF images and 10.4±10.8 mm2 in the ICGA images. There were no significant abnormal area differences between these two groups (p=0.81). In two eyes, however, the affected area differed markedly between IR-AF images and ICGA images.


Most abnormal areas appear similar on IR-AF and late-phase ICGA images. However, these two imaging modalities reveal and highlight different features. Therefore, both types of images should be interpreted carefully.

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