Correlation between optical coherence tomography angiography and fluorescein/indocyanin green angiography in choroidal neovascularization in wet age-related macular degeneration

Poster Details

First Author: P.Santos Ramos SPAIN

Co Author(s):    M. Fernandez   M. Gil Martinez   M. Rodriguez Cid   M. Abraldes Lopez-Veiga   F. Gonzalez   F. Gomez-Ulla de Irazazabal              

Abstract Details


To analyze choroidal neovascularization (CNV) in wet age-related macular degeneration (AMD) using multi-imaging. To correlate morphologic characteristics as well as CNV types


Department of Ophthalmology, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain. Instituto Oftalmológico Gómez-Ulla. Santiago de Compostela. Spain


All patients were evaluated with fluorescein angiography (Spectralis HRA; Heidelberg Engineering, Heidelberg, Germany) and optical coherence tomography angiography (OCT-A) (Angioplex, Cirrus HD-OCT models 5000; Carl Zeiss Meditec, Inc, Dublin, OH , DR1 Triton, Topcom corp., Japan). Indocyanine green angiography (ICGA)(Spectralis HRA; Heidelberg Engineering, Heidelberg, Germany) images were acquired in patients with suspected polipoidal choroidal vasculopathy or type III CNV


We have analyzed 63 eyes of 59 patients diagnosed with wet AMD. Standard CNV classification was followed in this study: type I, II, III and PCV. Correlation between both techniques was obtained in 97.61% in patients with type I CNV, 91.66% of type II, 100% of type III and 100% of mixed (type I + type II). Polipoidal lesions were not identified in any of the patients with PCV using OCT-A.


OCT-A is a fast, non-invasive technique useful in CNV. It allows to visualize Type I CNV and the hidden component of mixed CNV better than FA due to its location under the RPE, except when a high RPE detachment exists. In this cases it has been helpfull making a manual layer segmentation looking carefully for CNV. OCT-A has been specially useful to detect type I CNV without intraor subretinal fluid on OCT and to display the feeder vessel. ICGA has proven to be more useful in identifying polipoidal lesions in PCV whereas OCT-A allows to see the branching vascular networks in this condition.

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