Ganglion cell complex thickness may be used as an early predictor for microstructural changes in varying degrees of myopia in comparison with RNFL thickness

Poster Details

First Author: A.Pratiwi INDONESIA

Co Author(s):    H. Muhiddin   A. Muhammad Ichsan                          

Abstract Details


To compare the Ganglion Cell Complex (GCC) thickness with Retinal Nerve fibre Layer (RNFL) thickness in correlation with visual field (VF) in varying degrees of myopia.


Hasanuddin University Hospital, Makassar, South Sulawesi Indonesia


Patients examined with streak retinoscope to obtain the best corrected visual acuity based on the spherical equivalent. Patients divided into low (50 eyes=50.1%), moderate (31 eyes=32.3%), and high (15=15.6%) myopia. Axial length measured with A-Scan ultrasound is divided into short (4=4.2%), moderate (74=77.1%), and long (18=18.7%). SD-OCT was used to measured GCC thickness in 9 areas including fovea (R1), parafovea (R2-R5), and perifovea (R6-R9) according to early treatment diabetic retinopathy study (ETDRS), and RNFL thickness in five areas (G,TS,TI,NS,N,NI). VF analysis with humphrey field analyzer with SITA 24-2 pattern.


GCC thickness decreased significantly along with the elevation of myopia degree in almost entire area except R1 and R5. Parafovea (R2-R4) and perifovea (R6-R9) were significantly correlated with P= 0.001, 0.005, 0.006 and P= 0.000, 0.000, 0.000, and 0.003 respectively. In particular, R8 has the best AUROC value =0.772 among all perifovea area. In contrast, RNFL thickness obtained lower correlation with myopia degree whereas the only significant result was found in the nasal area (P= 0.045). Nasal RNFL has lower AUROC value when compared to R8 GCC (0.682). VF is found to be strongly correlated with the degree of myopia in which P value for Mean Deviation = 0.000.


GCC thickness may compare the predictive value of RNFL in predicting early retinal micro structural changes even in low degree myopia.

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