Posters

Follow-up of patients with PCV in CSCR treated with PDT or IVT of anti-VEGF; better ICGA or OCT-A?

Poster Details

First Author: E.Peiretti ITALY

Co Author(s):    E. Peiretti   G. Caminiti   R. Serra   C. Iovino                    

Abstract Details



Purpose:

Chronic central serous chorioretinopathy (CSCR) may predispose to the development of choroidal neovascularization (CNV) and polypoidal choroidal vasculopathy (PCV). The aim of the study is to evaluate OCT-A and indocyanine green angiography (ICGA) features in patients with Chronic CSCR complicated by PCV, before and after treatments.

Setting:

Prospective study of consecutive series of patient affected chronic CSCR complicated by PCV

Methods:

Eight eyes of seven consecutive patients with a diagnosis of PCV in chronic CSCR were analyzed on the basis of multimodal imaging. PCV patients were classified in 2 groups: the first group included 4 eyes treated with photodynamic therapy (PDT), the second group included 4 eyes treated with intravitreal injection (IVT) of anti-VEGF (bevacizumab, ranibizumab, aflibercept). OCT-A and ICGA were performed before and after treatment, in order to understand the effect of such therapies on the vascular networks. The fixed follow-up schedule was after 3 months for the PDT group and after 1 month for the IVT group.

Results:

At the baseline, in the whole series of patients, ICGA was able to detect 100% of the PCV and the data were confirmed by SD OCT analysis; OCT-A manual segmentation of different layers showed the polyp lesions either as an hyperreflective aneurysmatic dilatation surrounded by a dark halo or as an hypo-reflective round area. After therapy, in the first group (PDT treatment), the polyp lesions were not detectable either by ICGA as well as on OCT-A analysis in most of cases. In the second group (IVT of anti-VEGF), 75% of the eyes revealed the presence of PCV after treatment on ICGA while on OCT-A was difficult to confirm the presence of the aneurysmatic dilatations suggestive of PCV.

Conclusions:

OCT-A can be considered a valuable tool in order to detect the PCV in CSCR but is debatable its use in the follow up of photodynamic therapy and IVT of anti-VEGF.

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