Posters

Peripapillary and macular choroidal thickness in acute nonarteritic anterior ischaemic optic neuropathy

Poster Details

First Author: H.Nikkhah IRAN

Co Author(s):    M. Feizi   N. Abedi   A. Ramezani                       

Abstract Details



Purpose:

To study peripapillary choroidal thickness(PCT) in acute phase of nonarteritic anterior ischaemic optic neuropathy (NAION) in comparison to uninvolved fellow eyes and healthy control eyes.

Setting:

Ophthalmic Research centre, Shahid Beheshti University of Medical Sciences, Torfe Medical centre

Methods:

38 eyes from 38 patients with acute NAION (less than 14 days of initial symptom), 38 uninvolved fellow eyes and 76 eyes from 38 healthy age and sex matched subjects were included at a single academic hospital. Choroidal thickness was measured by enhanced depth imaging (EDI) of spectral domain optical coherence tomography (SD-OCT). Peripapillary choroidal thickness was measured at 1000 and 1500 microns from bruck´s membrane opening (BMO) at the superior, inferior, temporal, and nasal directions, using horizontal and vertical raster scans, centreed at optic nerve head. Subfoveal choroidal thickness was measured on horizontal raster scan at centre, and 500 microns apart in temporal and nasal sides. Ganglion cell-inner plexiform complex layer was measured using automated segmentation tool of OCT device. Statistical analyses were used to compare choroidal thickness among NAION eyes, uninvolved fellow eyes and control eyes.

Results:

The mean PCT at 1000µ was significantly thicker in NAION and fellow eyes compared to control eyes (mean PCT= 169.7±47, 154.4±42.1, 127.7±49.9 µm respectively, p=0.001 and p= 0.037, respectively). The mean PCT at 1500µ was significantly thicker in NAION and fellow eyes compared to control eyes (178.6±52.8, 162.6±46.1, 135.1±59 µm respectively, p=0.02 and p= 0.07, respectively). The mean PCT at 1000 and 1500µ was significantly greater in NAION compared to fellow eyes (p=0.02, p=0.04 respectively). The mean subfoveal choroidal thickness was significantly thicker in NAION compared to control eyes (p=0.024), however, there wasn’t any significant difference between uninvolved fellow and control eyes (p=0.2). Ganglion cell-inner plexiform layer thickness at fovea was significantly thicker in NAION eyes compared to uninvolved fellow and control eyes (p<0.001).

Conclusions:

Thicker peripapillary choroid in eyes with acute NAION and uninvolved fellow eyes compared to normal eyes may propound thick choroid as a risk factors for NAION. However more trials are needed to confirm this hypothesis

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