Label-free morpho-functional assessment of choroidal neovascularization: The role of cross-sectional OCT-Angiography

Poster Details

First Author: M.Lupidi ITALY

Co Author(s):    T. Fiore   G. Coscas   C. Cagini                       

Abstract Details


To determine the sensibility and specificity of combined cross-sectional optical coherence tomography (OCT) and OCT-Angiography (OCT-A) approach in detecting choroidal neovascularization (CNV) and to highlight its role in differential diagnosis between neovascular and non-neovascular maculopathies.


Department of Biomedical and Surgical Sciences, Section of Ophthalmology, University of Perugia, Perugia, Italy; Centre Ophtalmologique de l’Odéon, Paris, France


Fluorescein angiography (FA) and indocyanine green angiography (ICGA) findings [Protocol I] on the presence and status (active or quiescent) of CNV were compared with those obtained from cross-sectional OCT and OCT-A [Protocol II] to define the sensibility and specificity of each imaging protocol. The integrated analysis of morpho-functional B-scan images was also performed to describe the strengths and elucidate possible diagnostic drawbacks in different macular diseases.


Eighty-five eyes of 67 consecutive patients, suffering from different maculopathies, with suspected CNV were enrolled. Protocol I diagnosed a CNV in 76 of 85 eyes (89%), whereas a CNV lesion was clearly observed on Protocol II in 78 (92%) of 85 cases. Protocol I and Protocol II defined a lesion as active in 85% and 77% of the cases respectively. The sensitivity and specificity of Protocol II in detecting CNV seemed higher than Protocol I especially in case of inherited macular dystrophies, central serous chorioretinopathy and active multifocal choroiditis, while substantially similar results were obtained in case of neovascular age related macular degeneration.


Label-free cross-sectional OCT approach showed promising in detecting the presence and defining the status of CNV complicating different macular diseases. Although FA remains the gold standard in evaluating the retinal periphery, OCT and OCT-A offer a rapid, non-invasive moni¬toring of the retinal and choroidal structure and perfusion, aiding the diagnosis and treatment decisions during follow-up.

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