First Author: M.Lane UK
Co Author(s): E. Cole R. Louzada E. Novais J. Duker N. Waheed
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To compare choroidal neovascularization (CNV) area and artifacts found in optical coherence tomography angiography (OCT-A) images from two commercially available spectral-domain (SD) OCT-A devices, the OptoVue RTVue XR Avanti with AngioVue and Zeiss Cirrus HD-OCT with AngioPlex.
This is a prospective non randomized control study conducted at the New England Eye centre (NEEC) of Tufts Medical centre, Boston, Massachusetts and approved by the Tufts Medical centre and Massachusetts Institute of Technology Institutional Review Boards.
Patients with choroidal neovascularization were consecutively imaged on both SD- OCT devices with 3 x 3 mm and 6 x 6 mm angiographic scans centreed at the macula. Two independent and masked readers analyzed the OCT-A images from both devices to determine the presence and size of CNV and scored for the presence of artifacts.
There was no statistically significant difference (p>.05) between CNV area measured on both 3 x 3 mm and 6 x 6 mm scans on both devices. In the Avanti 3 x 3mm OCT-A, all 10 of the images had motion artifact, 6 had signal blockage, and 2 had blink artifact. In the Zeiss 3 x 3 mm OCT-A, 8 images had motion artifact, all 10 had signal blockage, and 1 had blink artifact.
Our study found no significant difference in the visualization and measurement of CNV area on OCT-A images taken on the two SD-OCT devices. There were slight differences in the qualitative assessment of artifacts, particularly motion artifact and signal blockage, but we cannot generalize from the small sample size of the current study.