First Author: R.Kurobe JAPAN
Co Author(s): K. Sugitani Y. Hirano T. Yasukawa Y. Ogura
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To evaluate the densitometry of choroidal vessels by binarizing wide-field indocyanine green angiography (ICGA) images in eyes with Vogt-Koyanagi-Harada (VKH) disease.
Retrospective, Observational, Consecutive case series.
Wide-field fluorescein angiography and ICGA images were obtained using a wide-field imaging device (Optos California; Dunfermline Scotland, UK) in 31 eyes of 21 patients (20 eyes with VKH and 11 control eyes). The densities of choroidal vessels in all eyes were measured as we previously reported (Hirahara S, et al. Am J Ophthalmol 2016) and compared between the eyes with VKH and the control eyes.
In the entire area, the mean choroidal vascular density of eyes with VKH was significantly (P < 0.05) lower than that of control eyes. In the posterior area, the vascular density of eyes with VKH was significantly (P < 0.05) lower than that of control eyes, whereas no significant difference was observed in the peripheral area. After steroid therapy for VKH, the choroidal vascular density was recovered, but still lower than that of control eyes.
Quantitative analysis of choroidal vascular densities showed significantly lower density in eyes with VKH, especially in the posterior area.