First Author: E.Kim SOUTH KOREA
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The purpose of this study was to invastigate the optical coherence tomography angiography (OCT-A) findings after single therapy (only intravitreal injection) or combination therapy (photodynamic therapy (PDT) and intravitreal injection) in patients with polypoidal choroidal vasculopathy (PCV).
Department of Ophthalmology, Kyung Hee University Hospital, Seoul, Korea
The study design was a retrospective chart review of 13 eyes with a clinical diagnosis of treatment-naïve PCV, seen at Kyunghee University Hospital between May 2016 and January 2017. All patients underwent ICGA, optical coherence tomography (OCT), OCT-A, fundus photography. ICGA and OCT-A was used to further analyze the polypoidal lesion and the BVN. Fundus photography and OCT was used to detect the subretinal haemorrhage, subretinal fluid and pigment epithelial detachment. Afibrecept and ranibizumab were used for intravitreal anti-VEGF injection.
Twenty eyes of 13 patients (10 male, 3 female) were studied. Average age was 68.43±9.07 years. Average number of intravitreal anti-VEGF injection was 3.5±1.2. single therapy (only intravitreal injection) was performed in 10 eyes and PDT combination therapy was performed in 3 eyes. The polypoidal lesions were detected in 13 eyes (100%) by ICGA and in 11 eyes (85%) by OCT-A. The BVN were detected in 7 eyes (54%) by ICGA and in 10 eyes (77%) by OCT-A. The subretinal fluid, pigment epithelial detachment and subretinal haemorrhage were detected in 11 eyes (85%), 6 eyes (65%) and 8 eyes (62%). 9 eyes were able to follow-up after single therapy and 2 eyes were able to follow-up after combination therapy. The decrease of polypoidal lesion and BVN after single therapy was detected in 6 eyes (67%) and in 6 eyes (67%). The decrease of polypoidal lesion and BVN after combination therapy was detected in 2 eyes (100%) and in 1 eyes (50%).
Branching vascular networks showed more clearly on OCT-A than on ICGA. Polypoidal lesions had variable patterns on OCT-A and showed more clearly on ICGA than on OCT-A. The OCT-A is a noninvasive imaging tool for detecting vascular changes in PCV and OCT-A patterns of the polypoidal lesions and the BVN are helpful in understanding the pathology of PCV and therapeutic effect.