First Author: U.Keklikçi TURKEY
Co Author(s): U. Karaalp A. Aslan F. Turkcu
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To evaluate optic nerve head flow density and radial peripapillary capillary flow density in glaucomatous eyes compared with normal eyes using optical coherence tomography (OCT) angiography.
OCT-Angiography safe and non-invasive device for quantitatively imaging human nerve head and RPC networks.
This a retrospective study including 39 eyes of 20 glaucoma patients and 42 eyes of 21 healty control subjects underwent OCT-Angiography (AngioVue, Optovue, Inc.) and RNFL imaging with spectral domain OCT. VF examination was performed using a Humphrey Field analyzer II, model 720i (Zeiss Humphrey Systems, Dublin, California, USA), with the Swedish interactive threshold algorithm standard 24-2 program.
Significant differences were found in nerve head (NH) whole en face, NH inside disc, radial peripapillary capillary (RPC) en face, RPC inside disc flow densities among the two groups (p<0.05). NH whole en face(p=0.02 rho:0.334), NH inside disc (p<0,001 rho:0.413), NH peripapillary (p=0.03 rho: 0.241), RPC en face (p<0.001 rho:0.426), RPC inside disc (p<0.001 rho:0.412), RPC peripapillary (p=0.042 rho:0.226) flow densities were correlated with temporal superior RNFL thickness. NH inside disc, RPC inside disc flow densities correlated with visual field mean deviation (p<0.001 rho:0.452 ; p<0.001 rh0:0.407 ,respectively) and pattern standard deviation(p=0.012 rho:-0.278; p=0.01 rho:-0.286, respectively) ; RPC en face (p=0.02 rho: -0.346) and RPC peripapillary (p=0.02 rho: -0.793) flow densities were correlated pattern standard deviation.
OCT-Angiography safe and non-invasive device for quantitatively imaging human nerve head and RPC networks. Nerve head and RPC flow densities decreased in glaucoma diseases compared with normal eyes. Further work is required to validate the role of OCT-Angiography device to determine whether the changes NH and RPC networks related to retinal blood ﬂow changes in glaucoma.