First Author: R.Hua CHINA
Back to previous
To investigate red-free angiography (RFA) findings in wet age related macular degeneration (wAMD) and polypoidal choroidal vasculopathy (PCV) using confocal scanning laser ophthalmoscope.
Retrospective case series study.
Following the venous phase of the fundus fluorescein angiography (FFA), the detection mode was switched to the red-free reflectance quickly (within 2-3 seconds), and RFA images were acquired under the same parameters as FFA.
RFA demonstrated the distinct staining of the retinal nerve fibre layer and lamina cribrosa in optic disc with the dye. Moreover, the better stereo structures of retinal vessels were also obtained through RFA as compared to FFA. Besides, the dye faded more quickly in RFA than that in FFA. For wAMD patients, RFA indicated the boundary of subretinal fluid, blood dots, retinal pigment epithelium turbulence and outer retinal tubulation more clearly, compared to both FFA and indocyanine green angiography. Additionally, compared with traditional FFA, RFA more clearly revealed the polyps as well as parts of the choroidal vessels in PCV patients and was in accordance with enhanced depth imaging-optical coherence tomography and ICGA findings.
RFA will provide more diagnostic imaging information, due to the differences in the mechanism of angiography modes, a mixture of both blue-light reflectance and fluorescence of fluorescein, the absorption coefficients of haemoglobins, and retinal chromophores. RFA will be a promising approach to supplement traditional FFA in wAMD and PCV patients.