First Author: R.Hua CHINA
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Optical coherence tomography angiography (OCT-A) based on mathematical processing of sequentially acquired structural OCT has been applied widely in both retinal and choroidal research, and may yield advantages over traditional angiography. However, optical phenomena and image processing algorithms may create imaging artifacts. OCT-A therefore require careful interpretation. In this review, the authors try to investigate choroidal vascular abnormal signals in OCT-A, with multi-factors analysis.
Retrospective case series study.
55 cases, including 20 normal eyes; 13 geographic atrophy eyes, 15 age related macular degeneration eyes, 8 polypoidal choroidal vasculopathy eyes, and 3 stargardt disease eyes examined by multi-colour imaging, swept source OCT-A with optical microangiography technique, and spectrum domain OCT-A with either full-spectrum amplitude decorrelation algorithm or split-spectrum amplitude-decorrelation angiography technique.
The choroidal dark vascular signals in OCT-A were related to the factors as the laser light penetration depth and masking effect of retinal pigment epithelium, the orientation of vessels compared with the scanning lasers and the intensity of blood flow, the regional detectable velocity range of blood flow, periphery atrophic tissues, or the absorption of superior vessels on the scanning laser.
Multi-factors should be taken into account simultaneously in order to get accurate and comprehensive interpretations of choroidal vasculature.