First Author: R.Gutierrez-Bonet SWITZERLAND
Co Author(s): J. Ruiz-Medrano M. Catanese C. Bergin E. Gabison J. Ruiz Moreno
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To determine the choroidal thickness (CT) profile in keratoconus (KC) patients using swept-source optical coherence tomography (SS-OCT).
Jules Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne.
Prospective, non-interventional study that analyzed 102 eyes of 51 KC patients diagnosed by Pentacam. The axial length (AL) of all included patients was under 26 mm. The macular CT profile was created by measuring the distance between the posterior edge of the retinal pigment epithelium and the choroid-sclera junction using manual digital callipers on images from Triton SS-OCT (Topcon Co., Japan). Nine measures were taken, at 0μm, ±1000μm, ±2000μm, ±3000μm, 4000μm and 5000μm. CT in KC results were compared to 160 eyes of 93 healthy age and gender-matched controls. ANOVA for repeated measures was used to perform the statistical tests (multiple locations) and correlation between eyes was accounted for in the statistical model.
Topographic KC classification (TKC, as calculated by Pentacam HR) was 2.0; 39 eyes were classified as early KC (TKC <1-2), 34 eyes as moderate (TKC 2, 2-3), and 29 as advanced (TKC 3+). Mean subfoveal CT was 383.2 μm in KC patients, whilst in healthy population was 280.5 μm (p< 0.001). CT in KC patients was statistically thicker in 8 out of the 9 measure locations (p< 0.001). CT in KC eyes thins quickly with age, approaching normal limits at 45 years old, where differences were no longer significant (p=0.37).
CT in KC patients is statistically thicker than healthy population. After age 45, CT decreases approaching normal values, possibly in relation with KC stabilisation.