First Author: A.Gomez Escobar SPAIN
Co Author(s): B. Dominguez Garcia M. Diaz Granda E. Gutierrez Sanchez A. Garrido Hermosilla E. Rodriguez de la Rua Franch
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To identify the different stages of type 3 neovascularization using OCT-Angiography (OCT-A). Type 3 NV is thought to arise predominantly from the deep capillary plexus of the retina and grow toward the retinal pigment epithelium (RPE), forming anastomosis with type 1 NV sub-RPE. Three stages are described: I Intraretinal NV, II Subretinal NV and III Choroidal NV.
Three eyes with type 3 neovascularization in different stages were scanned by swept-source OCT-Angiography.
In the first patient, OCT imaging shows a pigment epitelial detachment (PED) associated with hyperreflective density located in the outer nuclear layer, with RPE disruption. En face segmentation, OCT-A detects flow signals from the superficial and deep capillary plexus to the outer retinal layer (stage II). Patient 2: On SD-OCT, intraretinal fluid, DEP and hyperreflective lesion anterior to the RPE. OCT-A demonstrate weak flow signals in the deep capillary plexus, and type 3 neovascularization in outer retina, communicating with choriocapillaris (stage III). Patient 3: SD-OCT: intraretinal and subretinal fluid, advanced neovascularization. OCT-A shows a tuft-shaped high-flow signal in deep capillary plexus and outer retinal layer, characterized by a retinal-retinal anastomosis (stage III).
Based on understanding of the nature and progression of the neovascularization type 3, OCT-A can elucidate three vasogenic stages. Prognostic and treatment are different in each stage, so OCT-A may have a role in diagnosis and assessing the response to treatment.