Retinal changes in different stages of retinal artery occlusion: Quantitative analysis of retinal layers' optical intensities

Poster Details

First Author: O.Furashova GERMANY

Co Author(s):    E. Matthe                             

Abstract Details


To quantitatively investigate optical intensity of separate retinal layers in different stages of acute retinal artery occlusion (RAO).




DESIGN: Retrospective observational case series. PATIENTS: A total of 74 patients diagnosed with acute (symptom onset < 7 days) RAO examined with spectral domain optical coherence tomography (SD-OCT) at baseline. OBSERVATIONS: Based on funduscopic and SD-OCT findings, RAO was categorized into 3 stages: incomplete, subtotal and total. Optical intensity was measured using Adobe Photoshop Software (from 0=absolute black till 255=absolute white) 1000┬Ám from fovea in case of central retinal artery occlusion or in the region of occlusion in case of branch retinal artery occlusion. Optical intensity measurements were done for innermost retinal layer (IMRL; ganglion cell layer and inner plexiform layer), middle retinal layer (MRL; inner nuclear layer and outer plexiform layer), outer retinal layer (ORL; outer nuclear layer, external limiting membrane, ellipsoid and retinal pigment epithelium), preretinal vitreous body (VB). The measurements were compared across the three stages and with controls (contralateral eyes).


The optical intensity of VB showed no significant difference in incomplete, subtotal and total RAO as well as in controls (247; 247; 242; 246; p>0.05). Optical intensity of IMRL was statistically significant different across the three groups and controls with higher intensities in the higher occlusion stage (121; 90; 60; 157; p<0.01). MRL-reflectivity differed significantly between controls and all RAO (187; 116; p<0.01), but showed no significant difference across the three occlusion stages (108; 116; 128; p>0.05). Optical intensity of ORL was similar in controls compared with all RAO (223; 227; p<0,05), but it was statistically significant different across the three occlusion stages with lower intensities in higher occlusion (217; 229; 239; p<0.001).


RAO results in higher optical intensity of inner retinal layers (IMRL, MRL). Optical intensity of IMRL differs significantly across the three stages of RAO. Measuring optical intensity of inner retinal layers may provide useful information on the stage of ischaemic retinal damage.

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