First Author: M.Erol TURKEY
Co Author(s): E. Suren O. Yucel D. Turgut Coban B. Dogan A. Cengiz M. Bulut
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To investigate the effects of intravitreal anti-VEGF on photoreceptor maturation in preterm infants, on which intravitreal anti-VEGF treatment is applied and observed by spectral domain optical coherence tomography (SD-OCT).
In this study, we observed the treatment effect of anti vascular endothelial growth factor in preterm infants and investigated the photoreceptor maturation by SD-OCT.
36 preterm infants, with type-1 and aggressive retinopathy of prematurity (ROP), born before 32 weeks, were treated with intravitreal anti-VEGF. The study involved a total of 116 patients, whose SD-OCT were observed at least once during post menstrual 40-44th week. The formation of photoreceptor maturation central fovea Ellipsoid Zone (EZ) and formation of Cone Outer Segment Tips (COST) were evaluated by measuring the horizontal distance from EZ to central fovea.
Average PMA 41.4±1.8 week SD-OCT images were obtained. While in 50% of the infants treated with anti-VEGF, development of EZ was observed; a rate of 85% was observed in control group, which received no treatment (p<0.05). In infants who received treatment the distance of EZ to central fovea was 868 ± 440 µm; whereas, in untreated infants the distance was 725 ± 380 µm (p<0.05). The development of COST was not observed in any patients.
Early photoreceptor maturation was found to be connected to preterm birth week rather than ROP magnitude. In this study, we have shown that anti-VEGF treatment delays photoreceptor maturation. However, further study is needed to determine the effect of this delay on visual functions.