First Author: M.Entezari IRAN
Co Author(s): M. Arab H. Ghamary A. Ramezani A. Ashori A. Mowlazade. M. Yaseri
Back to previous
To evaluate peripapillary retinal nerve fibre layer (RNFL) thickness during and after pregnancy in pregnant women with pre-eclampsia or eclampsia and compare it with normotensive pregnant women as controls.
prospective comparative case-control study
In a prospective comparative case-control study 35 women (70 eyes) with mild to moderate pre-eclampsia, 70 women (140 eyes) with sever preeclampsia and eclampsia, and 44 (88 eyes) healthy pregnant women were enrolled in three groups. Peripapillary RNFL thickness in three groups was measured after 20 weeks of pregnancy and at 2 months postpartum by using optical coherence tomography. Mean and quadratic RNFL thickness changes were compared within and among the groups.
Mean peripapillary RNFL thickness decreased significantly from 104 ± 10, 104 ± 23, , and 106 ± 9 µm during pregnancy to 101 ± 10, 96 ± 10, and 103 ± 9 µm 2 months after pregnancy in the mild to moderate pre-eclampsia, sever preeclampsia and eclampsia, and healthy pregnant women groups, respectively (P<0.001 for all). While the difference among the groups were insignificant during pregnancy, it reached to a significant level after delivery (P=0.006). The highest reduction in mean RNFL thickness (-6 ± 10 microns) occurred in the sever preeclampsia and eclampsia groups.
In relation to the time of pregnancy, peripapillary RNFL reduced in preeclamptic and eclamptic cases as well as in normotensive pregnant women at 2 months postpartum. This reduction was more in the severe forms of pregnancy-induced hypertension.