Characteristics of central serous chorioretinopathy with or without choroidal neovascularization detected by optical coherence tomography angiography

Poster Details

First Author: T.Araki JAPAN

Co Author(s):    H. Fukuyama   H. Iwami   H. Ishikawa   F. Gomi                    

Abstract Details


It has been reported that optical coherence tomography angiography (OCT-A) can detect choroidal neovascularization (CNV) in central serous chorioretinopathy (CSC). The purpose of this study was to evaluate the frequency of the detection of CNV on OCT-A in eyes with CSC and any differences in the background characteristics with or without CNV.


This study was a retrospective, observational case series conducted at Hyogo College of Medicine.


We enrolled 63 eyes from 48 patients (42 men and 21 women having a mean age of 53 ± 11.4 years referred to the Hyogo College of Medicine Hospital that showed serous retinal detachment at the macula and were diagnosed as CSC by fluorescence angiography (FA) and indocyanine green angiography (ICGA) between May and December 2016. All cases underwent OCT-A and were divided into two groups: a CNV+ group in which the CNV structure was delineated in the slab of outer retinal layer or choriocapillaris, and a CNV- group. Age, gender, period from the onset, visual acuity, status of retinal pigment epithelial layer (RPE), central retinal thickness and choroidal thickness were compared between the 2 groups.


Choroidal neovascularization was detected in 17 of 63 eyes (27.0%) on OCT-A. In 2 cases of CSC without CNV, fellow eyes showed CNV without exudation. There were no significant differences in age, gender and the period from disease onset between the CNV+ group and the CNV- group. The mean LogMAR visual acuity was -0.002 ± 0.10 for the CNV+ group and 0.146 ± 0.26 for the CNV- group, significantly better in the CNV+ group (p=0.011). The flat, irregular RPE layer was observed at a significantly higher rate in the CNV+ group than in the CNV- group (94.1% vs. 41.3%, p<0.001). Central retinal and choroidal thickness were not significantly different between the groups (p=0.129, 0.402, respectively).


CNV is likely to occur in eyes with CSC, even in the fellow eyes. Because the background was not significantly different with or without CNV, it may be the common feature in CSC, especially in eyes with a flat elevated RPE layer.

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