Posters

Correlation between optical coherence tomography angiography findings and structural changes on SD-OCT in retinal vasculitis

Poster Details

First Author: N.Abroug TUNISIA

Co Author(s):    I. Khairallah-Ksiaa   S. Zina   S. Khochtali   R. Kahloun   S. Ben Yahia   M. Khairallah              

Abstract Details



Purpose:

To evaluate optical coherence tomography (OCT) angiography findings and the related structural changes on SD-OCT in eyes with retinal vasculitis.

Setting:

Department of Ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.

Methods:

Patients with retinal vasculitis of various aetiologies were enrolled in a retrospective observational study and evaluated using fluorescein angiography (FA), SD-OCT and swept-source OCT-Angiography. Abnormalities identified on OCT angiograms were described and correlated to the structural changes assessed by SD-OCT.

Results:

17 eyes of 14 patients were included. The diagnoses were Behçet's disease (14 eyes), rickettsiosis (1 eye), and West Nile virus infection (2 eyes). OCT-Angiography showed areas of capillary perfusion loss affecting the superficial and/or deep retinal vascular plexus in all eyes with retinal vasculitis. SD-OCT showed various structural changes corresponding to the areas of hypo-perfusion detected by OCT-Angiography. These changes included segmental thinning of the inner and/or outer retinal layers, change of the reflectivity of the retina and loss of visualization of normal retinal laminations. In 2 eyes with Behçet'sretinal vasculitis, SD-OCT showed a fovea-like aspect attributed to a focal loss of tissue filled by the outer nuclear layer and corresponding to an area of loss of signal flow on OCT-Angiography. In one eye with resolved rickettsial retinitis, with areas of capillary non-perfusion seen on OCT-Angiography, SD-OCT showed localized interruption of the ellipsoid zone with focal thinning, reflectivity change, and loss of visualization of retinal layers. In one eye with WNV chorioretinitis associated with macular occlusive retinal vasculitis, SD-OCT showed a focal thickening with increased reflectivity of the inner retina followed by thinning 3 weeks later.

Conclusions:

In this series of patients with retinal vasculitis, areas of capillary perfusion loss seen on OCT-Angiography corresponded to various structural changes on SD-OCT. This suggests that capillary flow abnormalities effectively assessed by OCT-Angiography could play a critical role in the development of retinal anatomic damage occurring in retinal vasculitis.

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