First Author: M.Zengin TURKEY
Co Author(s): O. Karti E. Karahan T. Kusbeci
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To evaluate the relationship between age-related macular degeneration (AMD) and clinically unilateral pseudoexfoliation (PEX) syndrome (XFS).
76 patients (152 eyes) with bilateral AMD and clinically unilateral XFS were included. Non-XFS fellow eyes were accepted as the control group. Eyes with AMD were divided into three stages (early, intermediate, and late), based on the Beckman Initiative for Macular Research Classification Committee of fundus findings. The distribution of AMD lesions were assessed in both groups, and the subfoveal choroidal thickness (SFCT) was measured using enhanced depth imaging from the spectralis domain optical coherence tomography (SD-OCT).
There were significantly more early- and intermediate-stage AMD cases in eyes with XFS than in non-XFS fellow eyes (p < 0.05). In contrast, there were significantly fewer wet AMD cases in XFS eyes than in non-XFS fellow eyes (p < 0.05). SFCT in all AMD stages was significantly lower in eyes with XFS (p < 0.05).
XFS was associated with a lower prevalence of wet AMD. Further studies are required to elucidate this association.