First Author: E.van Dijk NETHERLANDS
Co Author(s): C. Boon G. Dijkman
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To assess the effect of photodynamic therapy (PDT) in patients with chronic central serous chorioretinopathy (cCSC), in whom subretinal fluid (SRF) was solely present outside the foveal area, on visual complaints and findings on ophthalmological imaging.
General community, 1 referral university medical centre, outpatient care.
In this retrospective study, 16 eyes of 15 cCSC patients who received half-dose PDT because of notable subjective visual complaints due to the presence of extrafoveal SRF, were included. Standard ophthalmological examination and multimodal imaging, including fundus photography, fundus autofluorescence, spectral-domain optical coherence tomography (OCT), enhanced depth OCT, fluorescein angiography, and indocyanine green angiography were performed before treatment. The effect of treatment was assessed with standard ophthalmological and OCT examination.
In 8 treated eyes (50%) PDT led to a decrease in visual complaints at the first evaluation visit. At this visit, extrafoveal SRF on OCT had resolved in 14 eyes (88%), whereas a complete resolution of extrafoveal SRF had occurred in all eyes at final follow-up visit. At baseline, posterior cystoid retinal degeneration was also present in 5 eyes (31%), and at all evaluation visits this remained present in the same percentage of patients. In the treated eyes choroidal thickness showed a trend to decrease, both foveally and at the location of the maximum height of extrafoveal SRF.
Half-dose PDT treatment of cCSC patients with notable visual complaints due to extrafoveal SRF accumulation leads to complete SRF resolution, decreases choroidal thickness, and reduces visual symptoms.