One-year outcomes comparing anti-VEGF monotherapy and combined anti-VEGF plus photodynamic therapy for retinal angiomatous proliferation

Poster Details

First Author: M.Taskapili TURKEY

Co Author(s):    A. Demircan   C. Kesim   Z. Alkin   K. Fazil   A. Ozkaya                 

Abstract Details


To compare treatment results of age-related macular degenerative patients with retinal angiomatous proliferation (RAP) diagnosis receiving intravitreal anti-vascular endothelial growth factor (anti-VEGF) monotherapy against photodynamic treatment (PDT) combined with anti-VEGF treatment.


Retrospective, Case Control Study


A retrospective chart review of the patients with RAP who were treated in Retina Department of Beyoglu Eye Training & Research Hospital was conducted. Patients were divided into two groups: Patients received anti-VEGF monotherapy in Group I, and combined therapy with PDT in Group II. Best corrected visual acuity (BCVA) and central macular thickness (CMT) values at baseline and at months 6 and 12, number of anti-VEGF injections and PDT sessions were noted as well.


Fifteen eyes of 14 patients were included. Six of patients were female, 8 were male; mean age was 73.2±9.7. Mean baseline BCVA was 0.70±0.52 (LogMAR). Visual acuity increased in 1 of 15 eyes (6.6%), remained stable in 10 eyes (66.6%), and decreased in 4 eyes (26.6%). Seven eyes received anti-VEGF monotheraphy, 8 eyes received combined PDT and anti-VEGF treatment. Mean number of injections was 10.7±7.8. Five eyes received 1, 3 eyes received 2 sessions of PDT.


In this study, preserved visual acuity has been provided with anti-VEGF monotherapy and combined PDT + anti-VEGF treatment for RAP lesions.

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