A new clinical entity: Inactive neovascular age-related macular degeneration

Poster Details

First Author: J.Mentes TURKEY

Co Author(s):    S. Yildirim   I. Karaca                          

Abstract Details


To describe the imaging characteristics of asymptomatic, quiescent type 1 neovascularization (nv) in eyes with age-related macular degeneration (AMD).


Ege University, Faculty of Medicine, Department of Ophthalmology, Izmir, Turkey


Retrospective, observational case series. Thirty eyes of 27 treatment naive AMD patients who have asymptomatic, quiescent type 1 nv were included in the study. All patients underwent complete ophthalmological examination, including anamnesis, best corrected visual acuity (BCVA), slit-lamp biomicroscopy, Goldmann applanation tonometry, fundus photography (FP), Fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD–OCT), fluorescein angiography (FA) and indocyanine green angiography (ICGA).


The mean age of the patients (13 male, 14 female) was 69.5±8.2 years and the mean BCVA was 0.6±0.3 Snellen. On FA, although there was spesific hyperfluorescent staining for type 1 nv in all eyes (100%), no leakage was observed in any of the eyes until late stage. SD-OCT revealed an irregularly and slightly elevated retinal pigment epithelium (RPE) due to moderately reflective material in the subRPE space and hyperreflective Bruch’s membrane. However there was no evidence of intraretinal, subretinal and subRPE fluid on SD-OCT images. ICGA showed the presence of central macular plaques in 8 eyes in the late frames. On “En face” OCT images, hyperreflective lesions that might be compatible with type 1 nv localization were detected in 27 eyes.


Despite the absence of exudative signs on SD-OCT, FA and ICGA, there may be present quiescent, asymptomatic type 1 nv lesions in some eyes with AMD. They can be considered as a new clinical entity between exudative and nonexudative types of AMD and can be classified as an “inactive” or “ intermediate” AMD.

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