First Author: E.Loukianou CYPRUS
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To present the effect of the anti-VEGF factor aflibercerpt to the lateral eye after intravitreal administration to the other eye of a patient with a history of wet age-related macular degeneration.
Eye Clinic, Nicosia General Hospital, Cyprus
A 75- year-old woman was admitted to our clinic with a known history of wet age-related macular degeneration on both eyes. During the presentation, the best corrected visual acuity was 0.2 in the right eye and 0.5 in the left eye. The fundus examination in both eyes revealed retinal pigment epithelium changes with subretinal fluid bilaterally. The patient had received ten injections of another anti-VEGF agent in each eye in the past. The SD-OCT showed subretinal fluid in both eyes and intravitreal aflibercept was recommended, first in the right and then the left eye.
The patient received treatment with intravitreal aflibercerpt 0.2 mg / 0.05 ml in the right eye and after one week was admitted to receive the same treatment in the left eye. The SD-OCT showed significantly less subretinal fluid in the right eye and the disappearance of the fluid in the left eye. The best corrected visual acuity was 0.3 in the right eye and 0.7 in the left eye.
The intravitreal administration of aflibercept in a patient with age-related macular degeneration resulted in effect and to the other eye with disappearance of the subretinal fluid in that eye. This is the first time a lateral effect of this product is described and this may be a result of passing in the general circulation. Further research is needed to determine the mechanism by which the anti-angiogenic agent aflibercept passes into the systemic circulation.