Three-dimensional analysis of the morphological changes and visual outcomes in neovascular age-related macular degeneration

Poster Details

First Author: H.Lee SOUTH KOREA

Co Author(s):    H. Kim                             

Abstract Details


To investigate the association of three-dimensionally quantified lesions with best-corrected visual acuity (BCVA) in typical neovascular age-related macular degeneration (nAMD)


Retrospective study


We retrospectively analyzed 65 eyes of 61 typical nAMD patients. Lesions at baseline and month 12 were manually delineated in optical coherence tomography. The volume of intraretinal fluid (IRF), subretinal fluid (SRF), subretinal hyperreflective material (SHRM), and pigment epithelial detachment (PED) were measured. In addition, the areas of the external limiting membrane (ELM) and ellipsoid zone (EZ) were calculated.


At baseline, poor baseline BCVA was associated with the increased volume of IRF, SHRM and the impaired area of ELM (β=0.34, P=0.001; β=0.46, P<0.001 and β=-0.23, P=0.03). At month 12, poor BCVA was associated with the increased volume of the IRF and the reduction of intact ELM and EZ areas (β=0.24, P=0.01; β=-0.30, P=0.02 and β=-0.37, P=0.004). The baseline BCVA, volume of IRF, and intact area of ELM were the predictors for BCVA at month 12 (β=0.29, P=0.01; β=0.30, P=0.01 and β=-0.28, P=0.01). The change of BCVA was associated with the change of SHRM volume and of the intact EZ and ELM area (β=0.35, P=0.002; β=-0.28, P=0.01 and β=-0.22, P=0.048). The predictive power of the volumetric analysis was higher than that of the qualitative analysis (R2 = 0.47 vs. R2 = 0.37). The volume of SRF and fibrovascular PED showed weak positive and negative effect on visual outcome each.


BCVA could be explained to a fair degree by three-dimensional OCT morphology. Furthermore, visual outcomes could be better predicted by three-dimensional analysis than by qualitative analysis.

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