First Author: J.Kim SOUTH KOREA
Co Author(s): T. Rim H. Kim J. Kim S. Kim
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The present study aimed to evaluate the association between physical activity and incident neovacular age-related macular degeneration (nAMD) in adult Korea.
Retrospective nationwide longitudinal cohort study in Korea National Health Insurance Service database
This retrospective nationwide longitudinal cohort study included Korean men (age range: 45–79 years) registered in the Korea National Health Insurance Service database from 2002 through 2013. Incident cases of nAMD were identified from the database. We compared hazard ratios (HRs) for nAMD between participant who never engage in any physical activity (non-PA group) and who usually do physical activity (PA group).
There was 173,235 participants in non-PA group and 130,173 participants in PA group. The incidence of nAMD per 10,000 person-years in PA group and non-PA group among whole participant was 4.5 and 5.6, respectively (age- and sex-adjusted HR: 1.28; 95% confidence interval (CI): 1.09–1.50). This negative effect was more pronounced among men than among women (for men: HR, 1.48; 95% CI, 1.22-1.79 and for women: HR, 0.86; 95% CI, 0.62-1.18). More frequent usual physical activity in men was associated with a higher incidence of nAMD in a dose-dependent manner (P < .001 for trend; for participant who almost do not do physical activity as a reference group; for participant who usually do physical activity on 1-4 days/week: HR, 1.41; for participant who usually do physical activity on ≥5 days/week: HR, 1.63).
Longitudinally, more frequent self-reported physical activity was associated with a higher risk of nAMD in Asian men.