First Author: R.Hua CHINA
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To investigate the occurrence and progression of outer retinal tubulation (ORT) in Chinese patients after intravitreal anti-vascular endothelial growth factor (anti-VEGF) injection, and photodynamic therapy (PDT), using spectral domain optical coherence tomography (SD-OCT) with eye tracking function.
Retrospective case series study.
23 age related macular degeneration (AMD) and 9 polypoidal choroidal vasculopathy (PCV) eyes of 32 patients were enrolled and assessed by SD-OCT. Four patients received photodynamic therapy (PDT) previously, and all patients received intravitreal anti-VEGF injections (11 patients: conbercept; 21 patients: ranibizumab).
At baseline, four AMD eyes (17.4%) showed ORTs, which appeared as round or ovoid hyporeflective spaces with hyperreflective borders. During the follow ups, ORT was identified in 16 of 23 AMD eyes (69.6%) and only one of nine PCV eyes (11.1%). These new ORTs in 17 eyes were originated from the intraretinal fluid. Inner nuclear layer, outer plexiform layer and outer nuclear layer were pulled down to form 'cynapsis', separating each ORT. However, ORT in 5 eyes disappeared after intravitreal anti-VEGF injections.
This is the first observation on the occurrence and progression of ORT in Chinese AMD and PCV patients, in a point to point manner, especially after PDT and recombinant fusion protein (conbercept) therapy. The ORT could become stable or disappear after anti-VEGF injections, and outer retina involved in the process of ORT formation.