First Author: R.Fayzrakhmanov RUSSIA
Co Author(s): M. Bikbov
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To identify the incidence of epiretinal fibrosis and its impact on the anatomical and functional indices of the central region of the retina in patients with the wet form of age-related macular degeneration (AMD).
Ufa Eye Research Institute, Ufa, Russia
We observed 62 patients (64 eyes) with the wet form of AMD. Visual acuity, function of the central retinal area (MP1 Microperimeter, Nidek Technologies), ophthalmoscopy (78 D), optical coherence tomography (OCT) (SOCT Copernicus HR, Optopol technology) were performed.
It was determined that epiretinal fibrosis occurs in 7% of patients with retinal pigment epithelium detachment, 9% - with classic neovascular membrane, 17% with mixed neovascular membrane, 41% with active fibrovascular membrane and 62% with low activity level fibrovascular membrane. Patients of all groups were divided into 2 subgroups: 1) with epiretinal fibrosis, 2) without epiretinal fibrosis. Visual acuity in the first subgroup was 0.08 ± 0.02, indicators of light sensitivity – 1.4 ± 0.4 dB. In the second subgroup – 0.13 ± 0.03 (p> 0.05) and 3.8 ± 1.2 dB (p = 0.04), respectively. In the first subgroup of patients indicators of retinal thickness were 396.7 ± 80.7, height of neovascular membrane – 382.2 ± 47.7, the second subgroup – 261.3 ± 38 (p = 0.02), 286.4 ± 25.7 (p = 0.03), respectively.
The incidence of epiretinal fibrosis in wet form of AMD increases with disease progression. In patients with epiretinal fibrosis and the wet form of AMD, there was a statistically significant decrease in light sensitivity (p = 0.04), increase of retinal thickness (p = 0.03) and the height of neovascular membrane (p = 0.02) in comparison with data of patients without evidence of epiretinal fibrosis.