First Author: E.Esen TURKEY
Co Author(s): S. Sizmaz N. Demircan
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To evaluate the effect of intravitreal aflibercept on pigment epithelial detachment (PED) in patients with neovascular age-related macular degeneration.
Cukurova University, School of Medicine, Adana, Turkey.
This study included 73 eyes (37 treatment-naïve and 36 ranibizumab-resistant) of 61 patients with neovascular age-related macular degeneration and PED (>100 µm) who received at least 3 consecutive monthly injections of aflibercept. Change from baseline in best corrected visual acuity (BCVA), central macular thickness (CMT) and PED height were analysed. Factors influencing treatment response of PED height were investigated.
The mean BCVA improved from 1.01±0.47 LogMAR to 0.91±0.5 LogMAR (P=0.001). The mean CMT decreased from 465 ± 145 µm to 313 ± 108 µm (P<0.001); the mean PED height decreased from 309 ± 180 µm to 222 ±150 µm (P<0,001). The proportion of complete PED resolution after treatment was 6.8% (5 eyes). No significant correlation was found between PED height decrease and visual acuity changes. PED reduction was associated with higher PED at baseline (r=0.559, P<0.001). The mean PED height decrease was not significantly different in treatment-naïve eyes compared to ranibizumab-resistant eyes, and in serous PED compared to fibrovascular PED.
PED secondary to neovascular age-related macular degeneration showed significant functional and anatomic improvement after intravitreal aflibercept injections. Nevertheless, reduction in PED dimensions did not directly have effect on functional response.