Posters

Aflibercept therapy in eyes with neovascular age-related macular degeneration and its effect on choroidal thickness

Poster Details

First Author: A.Demircan TURKEY

Co Author(s):    A. Sariyeva   E. Esen   S. Sizmaz                       

Abstract Details



Purpose:

To evaluate the outcome of intravitreal aflibercept therapy in eyes with neovascular age-related macular degeneration and its effect on choroidal thickness

Setting:

Cukurova University medical faculty

Methods:

In this study, a total of 89 eyes of 76 patients who received intravitreal aflibercept injections for neovascular age-related macular degeneration were evaluated. The demographic characteristics, systemic diseases, lens status, previous therapies, duration of treatment, findings of optical coherence tomography and fundus fluorescein angiography were recorded. Patients were distributed into two groups. Group 1 included the treatment-naïve patients, group 2 included the patients who underwent another anti-VEGF therapy before the treatment of intravitreal aflibercept injection. The effectiveness of the treatment was studied by comparing the best corrected visual acuity (BCVA), central macular thickness (CMT) and choroidal thickness (CT) measured before and after injection. The association between aforementioned factors and change in BCVA, CMT and CT was investigated

Results:

The mean change in BCVA was statistically significant (0.18±0.34 LogMAR, p=0.01) in group 1, it was not statistically significant (0.092±0.38 LogMAR, p=0.131) in group 2. No statistically significant difference was observed between two groups in the mean change in BCVA. The mean change in CMT was 200.35±216.13 µm in group 1, 183.36±203.4 µm in group 2. Both of them were statistically significant (p<0.001 for both). No statistically significant difference was observed in the mean CMT change between two groups. The mean change in CT was statistically significant (22.19±62 µm, p= 0.014) µm in group 1. It was not statistically significant (22.28±74.05 µm, p=0.061) in group 2. No statistically significant difference was observed between two groups in the mean CT change. The changes in BCVA, CMT and CT were not found to be associated with gender, lens status, systemic disease, presence of pigment epithelial detachment, condition of IS/OS and type of choroidal neovascularization

Conclusions:

Intravitreal aflibercept is an effective treatment in neovascular age-related macular degeneration, for both treatment-naïve and resistant patients

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