First Author: R.Coco Martin SPAIN
Co Author(s): M. Pichel Mouzo
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To analyze the macular pigment density (DOPM) and its relationship with the diet in patients with age related macular degeneration (AMD).
Prospective observational study performed at the IOBA (University of Valladolid).
Only one eye of each patient was used for the study. A previously validated dietary questionnaire was passed to all study subjects. DOPM measurement was performed with the MPS 9000 instrument. Statistical analysis was performed with R version 3.1.1 software for Windows.
A total of 126 subjects (126 eyes) were studied: controls (n = 51 eyes); intermediate AMD (n = 54 eyes); and neovascular AMD (n = 21 eyes). No correlation between the DOPM and the diet was found in any group, neither in the short (previous day), medium (previous week) or long term (habitual feeding) diet (Rho control = -0.19, p-value = 0.1817, Rho intermediate = 0.0317, p-value = 0.8252, Rho neovascular = 0.2143, p-value = 0.5269, Rho total = -0.0359, p-value = 0.7055). For each year that an individual's age increased in the same AMD group and with similar short-term diet score, DOPM increased by a mean of 0.007 units (p-value = 0.0408). The logistic regression models were also not significant, explaining in 7% of the variability for the previous day's diet, 8.5% in the previous week's feeding and 7.8% of the usual long-term feeding.
There is no relationship between DOPM and the short, medium and long-term diet in controls and patients with intermediate or neovascular AMD measured with the MPS 9000 instrument, and therefore it cannot be used as an indicator of AMD at any stage.