Long-term remission of neovascular age-related macular degeneration with as needed anti-vascular endothelial growth factor therapy

Session Details

Session Title: Free Paper Session 27: AMD VI

Session Date/Time: Sunday 10/09/2017 | 12:00-13:30

Paper Time: 12:48

Venue: Room 117

First Author: : I.Muftuoglu USA

Co Author(s): :    M. Alam   R. Gaber   W. Freeman                       

Abstract Details


To determine the presenting characteristics of neovascular age-related macular degeneration (AMD) patientswith long-term remission (LTR), which was defined as the absence of intraretinal (IRF), subretinal fluid (SRF), orhaemhorrage on spectral domain optical coherence tomography (SD-OCT) and absence of leakage on fluorescein angiography (FA) for longer than 6 months while on as needed anti-vascular endothelial growthfactor treatment.




The presenting characteristics of patients with long-term remission was compared to control group including 32 eyes of 28 age, gender and ethnicity matched patients without achieving long-term remission.


Eyes with LTR at presentation had significantly thinner subfoveal choroidal thickness (147 vs. 178 μm, p=0.04). There was more IRF and less SRF at the presentation in the remission group compared to the control group (59.3% IRF and 11.1% SRF in the remission group vs. 28.1% IRF and 34.4% SRF in the control group, p=0.03). Seventy-four percent of patients in long-term remission group had type 1 choroidal neovascular membrane, retinal angiomatous proliferation was the second most common CNV type with a rate of 18.5%; whereas 28 eyes had type 1 CNV (87.5%),none of the patients had RAP in the control group (p=0.036).


Presence of RAP, thinner choroidal thickness and more IRF and less SRF at the presentation were associated with long-term remission in patients receiving as-needed treatment.

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