Polypoidal choroidal vasculopathy: A composite assessment of socio-demographic, behavioural and systemic associations

Session Details

Session Title: Free Paper Session 27: AMD VI

Session Date/Time: Sunday 10/09/2017 | 12:00-13:30

Paper Time: 12:30

Venue: Room 117

First Author: : V.Mutha INDIA

Co Author(s): :    A. Kumar                             

Abstract Details

Purpose:

To evaluate the socio-demographic, behavioural and systemic associations with Polypoidal Choroidal Vasculopathy (PCV) in North India. This study was done to assess the prevalence of formerly unknown factors such as lack of sleep, stress, socioeconomic status and exercise in patients with PCV in addition to previously studied factors such as diabetes, hypertension, heart disease, smoking, alcoholism, diet, sunlight exposure, obesity and homocysteinemia, because controversies exist amid various publications

Setting:

This study was done with adherence to the guidelines of the Declaration of Helsinki and was approved by the institutional ethics committee of All India Institute of Medical Sciences (AIIMS), New Delhi, India. All subjects consented for participation in the study. Study design: Observational case control study

Methods:

177 patients (cases) with unilateral or bilateral, Indocyanine green angiography (ICGA) diagnosed PCV were compared with “age and gender” matched subjects with different ocular disease presenting to the same ophthalmic centre (controls, n=177). All 354 subjects underwent a history based assessment of diet whether vegetarian or non vegetarian, past (within last 10 years) or present active or passive regular cigarette smoking, past (within last 10 years) or present > moderate regular alcohol consumption, daily average sleep hours, exercise, stress scores based on a 4 item Perceived Stress Scale (PSS), socioeconomic status, sunlight exposure, systemic diseases (hypertension, diabetes mellitus, ischaemic heart disease and hyperhomocysteinemia) and other ocular ailments. Assessment of obesity was based upon World Health Organisation (WHO) grading: obese (BMI > 30) or non obese (BMI < 30)

Results:

Mean age of PCV cases and “age and gender” matched controls was 66+6 and 66+9 years with 57% and 62% males, respectively. There was no statistically significant difference (p > 0.05) between the two groups with reference to diet, smoking, alcoholism, exercise, diabetes mellitus, ischaemic heart disease and plasma homocysteine. Stress, lack of sleep, obesity, hypertension and higher socioeconomic status (p < 0.05) were more commonly seen in PCV cases. Central Serous Chorioretinopathy (CSC) preceded PCV in 10% cases

Conclusions:

Stress, obesity, hypertension, lack of sleep and higher socioeconomic status are more prevalent in patients with PCV while diabetes, heart disease, smoking, alcoholism, diet and homocysteinemia are not.

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