AMD- Drusenoid deposits. Drusenoid deposits “L”, Lipid type and “P”, protein-cellular type, characterization, evolution, structural analysis with multimodal imaging and morphology-structural software

Session Details

Session Title: Free Paper Session 27: AMD VI

Session Date/Time: Sunday 10/09/2017 | 12:00-13:30

Paper Time: 12:12

Venue: Room 117

First Author: : C.Gonzalez FRANCE

Co Author(s): :                                 

Abstract Details

Purpose:

To study AMD drusenoid deposits “L”and “P”,with multimodal imaging and morphology-structural software and see all the input of this technique and software on drusenoid deposits knowledge and etiopathogenesis

Setting:

Interventional, non comparative, retrospective case series

Methods:

124 eyes of 74 patients, 23 men, 51 women, with AMD drusenoid deposits “L”, Lipid Type (soft Drusen, Drusenoid PED “L”)and “P”, Protein-cellular type (Pseudovitellifom AMD,Cuticular drusen, Subretinal drusenoid deposits(SDD), Drusenoid PED, ”P”). Deposits were evaluated by Autofluorescence, IR imaging, OCT, notably OCT en Face(Spectralis HRA-OCT, spectral domain OCT), and Morphology-Structural software (M-S software, (ADCIS) ). ETDRS visual acuity(VA),complete ophthalmic examination with Fundus exam were added. Size, characteristics, number, topography of the “L”and “P” deposits, their environment above and below (particularly IS-OS, plexiform layer, choriocapillaris structure and thickness)were evaluated, each element was studied, compared cut to cut, layer to layer and time to time. M-S software let analyze drusenoid deposit volume and contours, let a 3D deposit reconstruction, display in 3D space, let volume, density (grey levels of deposits), structure (structural measures, texture parameters), composition(density calculation) evaluation and characterization of those “L” and “P” type deposits

Results:

AMD Drusenoid Deposits: “L” are larger, roughly uniform, dome-shaped, dark grey, translucent, optical empty, equal and the same in all cross-section, as lipid pearl drops, fatty, mounds of deposit under the RPE, abnormal Pigment epithelium above, but layer quite preserved, evolution to atrophy; “P” are dense ,white, heterogeneous PED, below Pigment Epithelium, granular, as Protein, membranous, cellular component, as Basal Laminar Deposit, different in all cross-sections, abnormal Pigment epithelium above, heavily unstructured, layer interrupted, cells disappeared, irregular IS/OS facing, evolution to neovascularization. M-S software allows: grading(volume, contours analyze), measurements(volume, density, structure, composition),well differentiation, confirmation of difference between drusenoid deposits “L”type, and “P”type, selective characterization, so to better differentiate drusenoid deposits components and more

Conclusions:

Multimodal Imaging, Morphology-Structural Software contribute to and improve AMD Drusenoid deposits “L”, “P”, study and knowledge and so AMD etiopathogenesis understanding

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