Quantitative vascular flow analysis in non-proliferative diabetic retinopathy using optical coherence tomography angiography

Session Details

Session Title: Free Paper Session 25: Imaging IV

Session Date/Time: Sunday 10/09/2017 | 10:00-11:30

Paper Time: 10:42

Venue: Room 113

First Author: : M.Attia Ali Ahmed EGYPT

Co Author(s): :    H. Radi   A. Oribey                          

Abstract Details

Purpose:

To objectively assess the macular vascular flow and density using OCT-A automated software algorithms in diabetic patients with early background and non-proliferative diabetic retinopathy.

Setting:

Ophthalmology Department, Minia University Hospitals, Faculty of Medicine, Minia University, Minia, Egypt

Methods:

Forty-one eyes from 24 diabetic patients with twenty eyes of 10 normal individuals as controls were examined using OCT-A (RTVue-XR Avanti; Optovue, Inc, Fremont, CA). The flow area was measured and statistically compared between both groups and also correlated with the foveal thickness. Foveal avascular zone (FAZ) area, macular vessel density together with corresponding thickness and visual acuity (expressed as the logarithm of the minimum angle of resolution; Log-MAR) were measured in both groups and statistically compared.

Results:

Statistically significant negative correlation between flow area and foveal thickness (r = - 0.45, p = 0.003, sample size 41 eyes). The mean FAZ (non-flow) area was significantly greater in diabetic eyes (p = 0.001) and showed positive correlation with the Log-MAR visual acuity. Other qualitative biomarkers; integrity of the ellipsoid zone and COST line, cystic changes and presence or absence of neuro-sensory detachment were analyzed and correlated with visual acuity

Conclusions:

OCT-A is an emerging non-invasive imaging modality could be helpful tool to early detect macular micro-vascular flow changes and settle early treatment guidelines based on biomarkers and indices to modify the course of disease. The flow area could be reliable parameter to monitor the ongoing pathological process and treatment effects.

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