Changes in choroidal thickness after intravitreal injection of anti-vascular endothelial growth factor in pachychoroid neovasculopathy

Session Details

Session Title: Free Paper Session 22: AMD V

Session Date/Time: Sunday 10/09/2017 | 08:00-09:30

Paper Time: 09:12

Venue: Room 115

First Author: : N.Padrón Pérez SPAIN

Co Author(s): :    L. Arias   M. Rubio   D. Lorenzo   P. Garcia-Bru   J. Catala Mora   J. Caminal              

Abstract Details

Purpose:

To evaluate changes in choroidal thickness after intravitreal injection (IVI) therapy for pachychoroid neovasculopathy (PNV).

Setting:

Observational, retrospective, consecutive case series.

Methods:

The study sample consisted of 18 patients (18 eyes) who underwent anti-vascular endothelial growth factor (anti-VEGF) therapy for PNV. The 18 fellow eyes in these patients were used as a control group. All eyes were evaluated with swept-source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCT-A).

Results:

Mean patient age was 68.3±7.0 years. Mean follow up was 16.4±2.0 months. No differences in the best-corrected visual acuity (BCVA) of the affected eyes were observed between baseline and 12-month follow up (median ETDRS, 77.5 vs. 76 letters, P=.074; median LogMAR, 0.22 vs. 0.22, P=.453). However, subfoveal choroidal thickness (SFCT) decreased significantly, from a mean of 317.7±39.9 µm at baseline to 266.9±56.3 µm at 12 months (P≤.001). The median change in SFCT at 12 months was 44.0 µm (range, 17-133 µm). SFCT decreased by 16% from baseline to month 12. The change in SFCT at 12 months was highly correlated with the number of IVI (rs=0.762, P≤.001). No significant changes in SFCT were observed in the fellow eyes over the 12-month study period (median, 267.5 µm vs. 267.0 µm; P=.930).

Conclusions:

The present study reveals a significant reduction in choroidal thickness after 12 months of anti-VEGF intravitreal injections in eyes with PNV. Since PNV is part of the pachychoroid clinical spectrum, the decreased choroidal thickness in our patients might be attributable to a reduction in choroidal vascular permeability. The total number of intravitreal injections was highly correlated with the decrease in choroidal thickness.

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