The differential association of early age-related macular degeneration with environmental and genetic factors in a Japanese population

Session Details

Session Title: Free Paper Session 22: AMD V

Session Date/Time: Sunday 10/09/2017 | 08:00-09:30

Paper Time: 08:18

Venue: Room 115

First Author: : M.Sasaki JAPAN

Co Author(s): :    S. Harada   K. Tsubota   T. Takebayashi   Y. Nishiwaki   R. Kawasaki                 

Abstract Details

Purpose:

To investigate the cross-sectional gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors in a Japanese cohort.

Setting:

Population-based cross-sectional study.

Methods:

We included 11,001 subjects aged 35–74 years from among participants in annual municipal or worksite health check-up programs including fundus photographs in Tsuruoka, Japan. Of these, total of 3988 with fundus photographs with good quality for grading using the Wisconsin protocol for AMD were included in the main analysis of this study, and 3139 with both fundus photographs and genotyping data were included in the sub-analysis. Environmental and genetic risk factors were assessed by multiple logistic regression models.

Results:

Of 3988 participants, early AMD in men and women were present in 12.3% and 10.3%, respectively. After adjusting for potential risk factors, in men, higher levels of high density lipoprotein cholesterol (HDLC) was associated with increased odds of having early AMD (for each 1mol/L increase, OR: 1.61, 95% CI: 1.17-2.23), whereas higher levels of triglycerides (TG) was associated with reduced odds of having early AMD (for each 1mol/L increase, OR: 0.78, 95% CI: 0.64-0.96). In women, higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) were associated with increased risk of having early AMD (for 1mol/L increase, OR: 1.21 and 1.26, 95% CI: 1.01-1.44 and 1.03-1.53, respectively). Sub-analysis demonstrated that persons with CFH I62V and ARMS2 A69S polymorphisms, had a stronger risk for early AMD in women (OR: 3.25 and 2.04, 95%CI: 2.10-5.04 and 1.33-3.14, respectively) than in men (OR: 1.65 and 1.43, 95% CI: 1.02-2.69 and 1.02-2.69 and 0.88-2.32, respectively).

Conclusions:

In men, higher levels of HDLC and lower levels of TG were associated with increased risk of having early AMD. In women, higher levels of TC and LDLC were associated with increased risk of having early AMD. Further, known polymorphisms for AMD in Asian, having the CFH I62V and ARMS2 A69S polymorphisms, might be stronger risk for early AMD in women than in men. Differential associations of early AMD with both environmental and genetic risk factors by sex were demonstrated. Prospective longitudinal studies are warranted to confirm this observation.

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