Influence of multiple anti-VEGF injections on retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness

Session Details

Session Title: Free Paper Session 22: AMD V

Session Date/Time: Sunday 10/09/2017 | 08:00-09:30

Paper Time: 08:12

Venue: Room 115

First Author: : M.Zivkovic SERBIA

Co Author(s): :    M. Zlatanovic   G. Zlatanovic   V. Jaksic   M. Radenkovic   S. Jovanovic                 

Abstract Details

Purpose:

The aim of this study was to examine the changes in the retinal nerve fiber layer (RNFL) and ganglion cell - inner plexiform layer (GC+IPL) thickness in patients with wet form of age-related macular degeneration, after multiple applications of anti-VEGF injections.

Setting:

The study was performed at the Ophthalmology Eye Hospital-Clinic Maja, Nis, Serbia, using the Cirrus SD-OCT.

Methods:

The study enrolled 135 patients (70 women and 65 men), mean age 65 ± 15 years. All patients were diagnosed with age-related macular degeneration, exudative form. Exclusion criteria involved the presence of any other ocular disease, particularly glaucoma and neurologic diseases, previous ocular surgeries and laser interventions. Testing was performed at the Ophthalmology Eye Hospital-Clinic Maja, Nis, Serbia, using the Cirrus SD OCT. Average RNFL and GC+IPL thicknesses were evaluated as well as thicknesses in all sectors of RNFL and GC+IPL.

Results:

All patients were followed up for 24 months. The average number of injections per patient was 12.43±2.4. Average RNFL thickness prior to the first injection was 87.64±12.23, and after two years it was 86.23±12.55. Average GC+IPL thickness prior to the first injection was 47.23±15.45, and after two years it was 46.67±11.87. Changes in average RNFL and GC+IPL thickness, as well as in their sectorial thicknesses before and after drug administration were not statistically significant.

Conclusions:

Anti-VEGF does not lead to a statistically significant thinning of RNFL and GC+IPL layer over a period of 24 months following the initial dose.

Back to previous
EURETINA, Temple House, Temple Road, Blackrock, Co Dublin. | Phone: 00353 1 2100092 | Fax: 00353 1 2091112 | Email: euretina@euretina.org

Privacy policyHotel Terms and Conditions Cancellation policy